Supplements for DIY Clean Program

There are two ways to do the Clean Program:
1) Buy the Clean Kit from the Clean website.
2) A DIY Clean Program

The Clean Program used to offer a kit back in 2013 for $300, and now a new one which you can get for $475. The kit includes protein and fiber powders for shakes and extra supplements that helps you go along with your cleanse.

The $475 cleanse is a steep financial commitment to make, so I decided to go the DIY route. Knowledge is power, so I bought the much cheaper book – $10, Clean: The Revolutionary Program to Restore the Body’s Natural Ability to Heal Itself.

The book recommends taking some essential supplements as you’re doing the cleanse. It also strongly advertises the Clean Kit itself, but it isn’t required. So instead of buying the “official” kit, I figured out what it included and bought some of these supplements on my own.

The Clean Kit & Possible Substitutions

The older Clean Kit from 2013 included 8 items, and I’ve listed some possible substitutions for you:

What is it?
What’s in it &  Substitutes
When to take it?
Protein powder
Brown Rice Protein Powder
Such as: Naked Rice 1LB – Organic Brown Rice Protein
1 scoop/ shake
Fiber powder
Natural Fiber Colon Cleanse Powder (Rice Bran, Beet Fiber, Oat Fiber, Apple Fiber)
Such as: Super Colon Cleanse or just Flaxseed, Ground
1 scoop/ shake
Strong probiotic
Enhanced-potency probiotic formula (at least 15 billion organisms per dose)
Such as: Renew Life, Ultimate Flora Critical Care 50 Billion
1 per day in AM
Digestive enzyme
Supplies enzymes to support the breakdown of carbohydrate, protein, fat, and plant cellulose (Protease, Amylases, Lipases, Cellulases)
Such as: Enzymedica – Digest Gold
With each meal
Liver support
Supplement formulated to provide Advanced Support for Detoxification (Milk Thistle, Artichoke Leaf Extract, Watercress Whole Plant)
Such as: Metagenics, AdvaClear or just Milk Thistle
With each meal
Insulin regulator
Blend of: 180 mg Reduced Iso-Alpha Acids, Acacia Bark and Heartwood Extract
Such as: Metagenics, Insinase
With each meal
Probiotic anti-microbial
Saccharomyces Boulardii (7 billion minimum)
Such as: Nutricology Saccharomyces Boulardii, Vegicaps
1 per day in AM
Herbal anti-microbial
Roots of: Coptis (Extract containing berberine), Oregon Grape, Chinese Skullcap Root, Chinese Licorice, Chinese Rhubarb
Such as: Metagenics, Candibactin-BR
With each meal

How to do the Clean Program without the Clean Kit

Whew! The Clean Kit had quite a list right? If you add up some of the possible substitutions it does start adding up but I don’t think you really NEED all those supplements for the cleanse. In fact, the Clean book actually only lists 5 of them as essentials:
  • Fiber aka “Nourish”. It absorbs water and creates bulk which triggers movement in your intestines and promotes bowel movement. By the way, the common theme of the book is, well… poop. That’s how you clear out your body right?
  • Probiotics aka Encourage. Helps with the restoration of hundreds of different species of good intestinal bacteria, the book recommends that it has at least 15 billion organisms per dose.
  • Antimacrobials aka Clear 1 & 2. This helps kill the pathogenic (bad) bacteria. A lot of foods we eat contains this, garlic, lemon, olive oil, onions, etc. Other recommendations are Oil of Oregano, eat a raw clove of garlic a day, or in pill form if you don’t want to eat raw garlic. There are also herbal antimicrobials such as berberine, licorice root, rhubarb root, skull cap root, ginger root, etc.
  • Liver Support aka Relief. Boosting your liver’s ability to help you detox. Can be a single ingredient or a combo of some of the following: milk thistle (sylimarin), dandelion root, wormwood leaf, etc.
  • Olive Oil. Take 2 tablespoons before bed to help lubricate your intestines, improve bowel elimination, provide anti-inflammatory fats, the list goes on… I mean, the New England Journal of Medicine recently published a study about “Primary Prevention of Cardiovascular Disease with a Mediterranean Diet”. And what’s a part of a strong Mediterranean Diet, olive oil.
Refrigerated Probiotics section at Whole Foods, who knew there’s so many choices!?


Supplements for The Clean Program, the easy way

Note: I’m not claiming that the supplements listed will replace the Clean Kit, I am adding to the discussion of a more affordable alternative to the kit itself. Please consult a doctor if you have any concerns about starting this cleanse. 

I’ll be honest, it’s a big enough of an effort for me to mentally put the effort into doing this three week cleanse, so I didn’t really feel like shelling out the big bucks for supplements. When I did it last year, I stuck to the basics:

  • Fiber – ground flaxseed to add to shakes
  • Probiotics – Ultimate Flora with about 50 billion organisms, picture below
  • Liver Support – Milk Thistle
However, this time around, since I did more research (partly for this blog, so thank you for reading!), I decided to start adding more into the rotation.

I came across a lot of “total cleanse” kits at the health food aisle that I didn’t see the last time I was cleansing. Take Whole Food’s 365 Complete Body Cleanse Kit for example. This kit includes 3 things: fiber, digestive supplements, and liver support. Hmmmm, sound familiar? It matches up with 3 of the key items from the Clean Kit. Except this one is a lot cheaper.

Update: I ended up buying the Complete Body Cleanse from Whole Foods, I’ve reviewed it here. Definitely recommend it as a part of the cleanse. 

So with a bit of mix and matching, I think you can get something that’s similar to the kit. With the kit listed above, it is missing 5 things: a strong probiotic, protein powder, an insulin regulator, and the two anti-microbials (herbal and probiotic).

The first two should be an easy fix – just grab a bottle of probiotics and then some Brown Rice Protein Powder. For anti-microbials, you can consider taking Oil of Oregano and eat raw pieces of garlic/take garlic pills. If you really feel like getting the insulin regulator and more anti-microbials, then you can look up at the chart above for comparables. I think those formulas aren’t items you would typically find pre-packed for you at a health food store.

Hopefully this helps you as you navigate through the store to pick up supplements for the cleanse. If you’re eating from the elimination diet, that’s already a great accomplishment! These few items will only help enhance your cleanse and probably help induce more – dare I say it – bowel movement.

Feel free to leave a comment below if you have any questions about this and I’ll do my best to help answer you.

To begin doing this cleanse yourself, see Starting The Clean Program & Grocery List for Clean Living.

Also check out when I did the cleanse last year in Why I’m Doing The Clean Program.

Leave a Comment


  1. Aziza Roc wrote:

    Thanks so much for your experience and offering parallel options to do the Clean Program. I’m sure it’s been slightly updated from the 2013 version but I’m still excited to do it nonetheless, especially after reading Clean Gut. Thank you!

    Posted 4.21.22 Reply
    • Shelly L. wrote:

      Glad it was helpful for you Aziza! I haven’t read Clean Gut but now you’re making me curious to. Best of luck on your cleanse! 🙂

      Posted 5.11.22 Reply